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Case Study

Delivering a Next-Generation Automated Sample Preparation and Imaging System

Overview

Improving Performance, Manufacturability, and Cost Efficiency

A global life sciences company sought to develop a next-generation automated sample preparation and imaging system to replace an existing platform. The goal was to reduce cost and build complexity while improving manufacturability, system performance, and long-term scalability. Ascential delivered a redesigned system that simplified the architecture, strengthened performance, and enabled more efficient manufacturing.

Cost reduction achieved through design simplification and manufacturability improvements
0 %
Delivered on schedule and under budget
On-Time 0
Redesigned system optimized for performance, reliability, and manufacturability
Next-Generation Platform 0

The Challenge

The existing system had been in production for over 15 years and had become complex and costly to manufacture. The client needed a next-generation platform that could:

Reduce Cost & Complexity

Simplify the system design to lower manufacturing cost and streamline assembly.

Improve Manufacturability

Reduce part count, integrate components more efficiently, and decrease build time.

Enhance Performance & Reliability

Improve optical performance, motion control, and overall system robustness.

Enable Long-Term Scalability

Ensure the system could be manufactured efficiently at scale while supporting evolving market needs.

Ascential's Solution

Ascential led a comprehensive redesign of the platform, applying design for manufacturability principles and integrating cross-functional engineering expertise across optics, motion systems, fluidics, and mechanical design.

Key elements of the solution included:

  • Simplified system architecture through part reduction and integration of sensors into printed circuit boards
  • Co-development of a custom system integrating advanced optics, precision motion control, and complex sheet metal design
  • Development of a proprietary in-house optical solution to improve performance and quality control
  • Design optimization focused on improving manufacturability, reducing build time, and ensuring repeatable performance

This integrated approach enabled the delivery of a robust, next-generation platform with improved manufacturability and performance.

Technical Capabilities Delivered

CapabilityWhat Ascential Built
Automated Sample ProcessingAutomated sample preparation with fluid immersion and integrated thermal hybridization workflows
Optics & Imaging SystemsCustom in-house optical system to improve performance, stability, and quality control
Precision Motion SystemsHigh-precision motion architecture integrated with advanced mechanical design for accurate sample handling and imaging
Fluidics IntegrationLinked fluidics and imaging workflows enabling sample transfer and controlled processing
Mechanical Design & FabricationComplex sheet metal and structural design
Design for ManufacturabilitySimplified architecture, reduced part count, and sensor integration into printed circuit boards

Key Results

  • 30% cost savings achieved through design simplification, component integration, and improved manufacturability
  • Reduced build time and improved manufacturing efficiency
  • Improved system performance and quality control through in-sourced optics and integrated system design
  • On-time, under-budget delivery supporting a successful platform transition
  • A scalable, next-generation platform designed for long-term production and market adoption

Why It Matters

Complex life sciences instrumentation requires a balance of performance, manufacturability, and cost efficiency. By simplifying system architecture, integrating critical subsystems, and applying rigorous engineering discipline, this next-generation platform delivers meaningful improvements in manufacturing efficiency and long-term scalability.

The redesigned system enables more efficient production while maintaining high performance and reliability—supporting the client’s ability to deliver advanced analytical capabilities to the market at scale.