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Applications | Production Automation | Oligonucleotide Synthesis

Build GMP-ready oligonucleotide synthesis platforms

Ascential designs manufacturing solutions for a full range of synthesis scales — from femtomoles to moles. We build the precision hardware, fluidic control systems, and GMP-ready platforms you need to ensure accurate reagent delivery, contamination control, and scalable production, including:

  • DNA and RNA Oligonucleotide Synthesizer Platforms
  • mRNA Building Block Production Equipment
  • Microarray Production Systems
  • Automated Reagent Delivery and Fluid Handling Modules
  • Post-Synthesis Processing Automation 
  • Production Automation Equipment for Consumable Assembly and QC
  • Phosphoramidite-Based and Enzyme-Based Synthesis Platforms
  • Research-Use-Only Benchtop Synthesizers
  • High-Throughput GMP Oligonucleotide Manufacturing Systems
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Solutions

Eliminate oligo production risks with validated manufacturing processes

Ascential designs integrated serviceable platforms by validating reagent precision, moisture mitigation, and maintenance intervals at early design stages. We optimize your workflows and engineer systems that can scale without a ground-up redesign.

Oligonucleotide Synthesis Platform Development

Monitor processes in real time with high-precision stage and safety systems and robust instrument control software. We can engineer production-scale platforms that handle steps like lithography integration and multi-substrate processing.

Synthesis Consumable Design & Manufacturing

Design and produce disposable fluidic kits, reagent cartridges, and serviceable fluidic assemblies optimized for chemical compatibility, low dead volume, and scalable manufacturing.

Production Automation & Equipment Development

Drive automation of consumable assembly, inspection, quality control, and post-synthesis processing, with factory-level integration of reagent supply and waste handling.

Manufacturing Process Development

Streamline production transfer and scale-up with tolerance analysis and manufacturing processes developed for your fluidic manifolds, chemical-resistant subsystems, and precision mechanical assemblies.

Volume Manufacturing

Expand manufacturing capacity for synthesizer platforms and automation equipment with process controls to ensure fluidic precision and long-term system reliability.

Sustaining Engineering & Cost Optimization

Save time and money with ongoing improvements to valve and pump durability, yield optimization, component obsolescence management, and cost reduction through VAVE.

Capabilities

Reliable fluidic & chemical engineering

Oligonucleotide synthesis platforms require tight coordination between multi-reagent delivery, chemical durability, environmental control, and process monitoring. We deliver that integration with materials handling, automation, manufacturing, engineering, and supply chain management, all in one cohesive strategy.

Precision Fluid Delivery & Flow Path Engineering

Achieve higher coupling efficiency per cycle, lower reagent consumption per synthesis run, and batch-to-batch consistency across production shifts. We engineer multi-reagent dispensing systems with microliter-scale accuracy and repeatability and optimize valve manifold geometry to your specifications.

Scalable Platform Architecture

Support parallelization and mechanical repeatability while avoiding ground-up redesign with a modular platform architecture. Our team scales your single-column research synthesis by integrating multi-substrate handling and closed-loop process control into your system configurations.

Chemical Durability & System Reliability

Improve uptime and more accurately predict maintenance schedules by using measured degradation data for all your wetted-path materials, seals, tubing, valves, and pumps. Ascential helps you minimize costly production line stops due to seal failures, corrosion, or moisture contamination.

GMP-Ready Design & Manufacturing

Ensure your equipment is qualified for GMP production environments. We develop design controls and handle verification, validation, and risk management in accordance with ISO standards. Get a cleanroom-compatible enclosure design that meets the documentation and traceability requirements for therapeutic oligo production.

Case Study

Standardizing oligo synthesis operations with a scalable platform

A global biotech leader handling oligo synthesis across multiple facilities needed to replace legacy equipment from different manufacturers with a single upstream platform that would standardize processes, reduce reagent waste, and improve serviceability. Ascential delivered:

  • Unified synthesizer architecture
  • Advanced chemistry integration and updated equipment for improved performance, reliability, and maintenance
  • Reduced manual handling, reagent waste, and process variability across facilities

The scalable, consistent platform advanced into qualification trials, allowing the company to strengthen its market position and gain more control over costs.

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Why Choose Ascential?

When you engage our team, you tap into 70+ years of experience delivering mission-critical solutions that bridge precision engineering, automation, and medical manufacturing knowledge from 7 highly specialized firms.

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Oligo Synthesis Platform Experience

We manufacture synthesizer platforms and production automation equipment for leading life science companies. Our team works with you to solve precision and integration challenges and optimize processes against reagent waste per cycle and maintenance realities, not just flow specs.

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Integrated Engineering

Resolve design trade-offs with an integrated team capable of handling systems engineering, precision fluidics, mechanical, thermal, optics, automation, embedded software, and consumable manufacturing.

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Volume Manufacturing

Get consistent, reliable platforms designed to your exact specifications, functionality requirements, and fluidic tolerance budgets. Ensure the fifth unit performs like the first without engineering intervention.

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Production Automation Beyond the Synthesizer

We design and build automation for consumable assembly, inspection, and QC processes — applying the same materials expertise to all production steps you need to scale alongside your synthesizers.

Frequently Asked Questions

Get answers to common questions about our oligonucleotide synthesis capabilities.

No. Ascential engineers instrument platforms, fluid delivery systems, and automation hardware. Your team owns the chemistry. We engineer the equipment to deliver your reagents with the precision, chemical compatibility, and contamination control your process requires.
Ascential manufactures synthesizer platforms and production-scale synthesis systems used by leading genomics and life sciences companies today. We have direct experience solving the following engineering challenges: precision multi-reagent delivery, dead-volume minimization, chemical durability in synthesis solvents, moisture control, and scaling from bench-scale synthesis to high-volume production equipment.
We have sites in the U.S., Southeast Asia, Ireland, and Costa Rica. We use U.S. sites for development and pilot builds where engineering proximity matters, and Southeast Asia for volume manufacturing to meet the cost targets required for production-scale equipment deployment.
Yes. Valve manifold optimization and dead volume reduction are core to our synthesis platform work. Our experts design flow-path geometry, valve sequencing, and purge protocols to minimize reagent waste per synthesis cycle, not just based on volumetric specs.
Yes. We design system enclosures for cleanroom classifications your GMP production requires and develop both disposable and serviceable fluidic kits optimized for chemical compatibility, low dead volume, and high-volume manufacturing. Our consumable design work includes reagent cartridges, valve manifolds, and sealed fluidic assemblies engineered for your specific synthesis chemistry and production throughput.
Yes. We design and build automation for post-synthesis workflows, including cleavage, deprotection, desalting, plate stamping, dry-down, and packaging. For factory-level operations, we integrate reagent supply and waste management systems, optimize pump and valve lifecycles to enable predictable maintenance, and work with digital manufacturing partners when your production architecture requires external system integration.

A targeted subsystem redesign or next-generation upgrade can run 6-12 months. A full synthesis platform from concept through design verification typically runs 12-24 months, with GMP production systems requiring environmental control, safety systems, and process validation, which tend to be toward the longer end.

Either. Ascential routinely integrates client-preferred suppliers for valves, pumps, reagent-specific wetted materials, and process monitoring components. Where you don’t have a preference, we use our qualified supply base. For components exposed to synthesis solvents, we recommend qualifying alternatives early since chemical compatibility failures are expensive to discover in production.

Related Resources

Get lifecycle support for oligo synthesis production

Learn how Ascential can support your synthesis platform development, fluidic control optimization, and production automation needs.
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